Research

Neurocognition - Basal Ganglia

My research focuses on the basal ganglia, a group of subcortical regions involved in motor control and various cognitive functions. Using spiking and rate-coded neural networks inspired by the biological system, I explore potential cognitive functions such as reinforcement learning, reversal learning, action cancellation, and outcome prediction.

A cueing experimental procedure

  • Exploration behavior after reversals is predicted by STN-GPe synaptic plasticity in a basal ganglia model. iScience. (2023).

  • A spiking model of basal ganglia dynamics in stopping behavior supported by arkypallidal neurons. European Journal of Neuroscience. (2021).

  • Optimal attention tuning in a neuro-computational model of the visual cortex–basal ganglia–prefrontal cortex loop. Neural Networks. (2021).

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Parkinson’s Disease & Deep Brain Stimulation

The basal ganglia play a crucial role in neurological disease such as Parkinson’s Disease. Using computational models of the basal ganglia, combined with experimental neurological and imaging data, I investigate how disease-related changes affect basal ganglia circuitry and how treatments like Deep Brain Stimulation can influence these pathological circuits.

Basal Ganglia Activity Changes caused by Parkinson's Disease

  • Virtual deep brain stimulation: Multiscale co-simulation of a spiking basal ganglia model and a whole-brain mean-field model with The Virtual Brain. Experimental Neurology. (2022).

  • A computational model-based analysis of basal ganglia pathway changes in Parkinson’s disease inferred from resting-state fMRI. European Journal of Neuroscience. (2021).

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Neuroinformatics

I build and simulate my neurocomputational models using the Python neurosimulator ANNarchy. I have developed a method that enables the simulation of Blood Oxygen Level Dependent (BOLD) signals from ANNarchy networks. Additionally, I am working on my own Python extension for ANNarchy called CompNeuroPy, which, for example, facilitates structuring code and implementing experimental procedures and allows for the simulation of Deep Brain Stimulation in both rate-coded and spiking ANNarchy networks.

Firing Rate to BOLD Signal

  • BOLD Monitoring in the Neural Simulator ANNarchy. Frontiers in Neuroinformatics. (2022).

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